منابع مشابه
The Ino80 chromatin-remodeling complex restores chromatin structure during UV DNA damage repair
Chromatin structure is modulated during deoxyribonucleic acid excision repair, but how this is achieved is unclear. Loss of the yeast Ino80 chromatin-remodeling complex (Ino80-C) moderately sensitizes cells to ultraviolet (UV) light. In this paper, we show that INO80 acts in the same genetic pathway as nucleotide excision repair (NER) and that the Ino80-C contributes to efficient UV photoproduc...
متن کاملINO80 and γ-H2AX Interaction Links ATP-Dependent Chromatin Remodeling to DNA Damage Repair
(Shen et al., 2000). However, it is not known whether the INO80 complex functions in DNA damage repair Waltham, Massachusetts 02454 directly or indirectly through other mechanisms. Here, we show biochemical and genetic evidence that the INO80 complex is directly involved in DNA repair. The Summary key mechanism is through a specific interaction between the INO80 complex and the DNA damage-While...
متن کاملFunction of the INO80 chromatin remodeling complex in DNA replication.
ATP-dependent chromatin remodeling complexes are involved in several nuclear processes. In particular the INO80 remodeling complex is an essential factor during transcription and DNA repair. Recently, several labs have described a novel role for INO80 during DNA replication. Moreover, Falbo et al. have presented evidence linking INO80's activities to the DNA damage tolerance pathways during rep...
متن کاملSnapShot: Chromatin Remodeling: INO80 and SWR1
The INO80 and SWR1 complexes belong to the INO80 subfamily of ATP-dependent chromatin-remodeling complexes. These complexes interact with nucleosomes and remodel chromatin by either sliding nucleosomes along the DNA or exchanging histones within nucleosomes. In doing so, the INO80 and SWR1 complexes promote recruitment of regulatory factors to DNA. Distinct from other subfamilies of chromatin-r...
متن کاملChromatin Remodeling, DNA Damage Repair and Aging
Cells are constantly exposed to a variety of environmental and endogenous conditions causing DNA damage, which is detected and repaired by conserved DNA repair pathways to maintain genomic integrity. Chromatin remodeling is critical in this process, as the organization of eukaryotic DNA into compact chromatin presents a natural barrier to all DNA-related events. Studies on human premature aging...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.5.a889-a